Pharmacokinetic Characteristics, Tissue Bioaccumulation and Toxicity Profiles of Oral Arsenic Trioxide in Rats: Implications for the Treatment and Risk Assessment of Acute Promyelocytic Leukemia

• Ngā kaituhi matua: Wensheng Liu (Author), Bin Wang (Author), Yilei Zhao (Author), Zhiqiang Wu (Author), Andi Dong (Author), Hongzhu Chen (Author), Liwang Lin (Author), Jing Lu (Author), Xin Hai (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Oral arsenic trioxide (ATO) has demonstrated a favorable clinical efficiency in the treatment of acute promyelocytic leukemia (APL). However, the pharmacokinetic characteristics, tissue bioaccumulation, and toxicity profiles of arsenic metabolites in vivo following oral administration of ATO have no...