p19-targeted ABD-derived protein variants inhibit IL-23 binding and exert suppressive control over IL-23-stimulated expansion of primary human IL-17+ T-cells

• Main Authors: Lucie Křížová (Author), Milan Kuchař (Author), Hana Petroková (Author), Radim Osička (Author), Marie Hlavničková (Author), Ondřej Pelák (Author), Jiří Černý (Author), Tomáš Kalina (Author), Petr Malý (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin-23 (IL-23), a heterodimeric cytokine of covalently bound p19 and p40 proteins, has recently been closely associated with development of several chronic autoimmune diseases such as psoriasis, psoriatic arthritis or inflammatory bowel disease. Released by activated dendritic cells, IL-23 i...