Pharmacogenomics of mycophenolic acid in kidney transplantation: Contribution of immune response-related genes

Pharmacogenomics of mycophenolic acid in kidney transplantation: Contribution of immune response-related genes

Abstract Mycophenolic acid (MPA) inhibits IMPDH, involved in the guanosine nucleotides synthesis, and prevents DNA replication in immune cells. The repression of cell and humoral immunity by MPA induces allograft tolerance preventing acute rejection in solid organ transplantation. MPA is an effectiv...

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Main Authors: Rosario Dominguez Crespo Hirata (Author), Fabiana Dalla Vecchia Genvigir (Author), Thiago Dominguez Crespo Hirata (Author), Alvaro Cerda (Author), Mario Hiroyuki Hirata (Author)
Format: Book
Published: Universidade de São Paulo, 2023-01-01T00:00:00Z.
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