Pharmacogenomics of mycophenolic acid in kidney transplantation: Contribution of immune response-related genes
Abstract Mycophenolic acid (MPA) inhibits IMPDH, involved in the guanosine nucleotides synthesis, and prevents DNA replication in immune cells. The repression of cell and humoral immunity by MPA induces allograft tolerance preventing acute rejection in solid organ transplantation. MPA is an effectiv...
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Universidade de São Paulo,
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