Pharmacogenomics of mycophenolic acid in kidney transplantation: Contribution of immune response-related genes

• Главные авторы: Rosario Dominguez Crespo Hirata (Автор), Fabiana Dalla Vecchia Genvigir (Автор), Thiago Dominguez Crespo Hirata (Автор), Alvaro Cerda (Автор), Mario Hiroyuki Hirata (Автор)
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• Опубликовано: Universidade de São Paulo, 2023-01-01T00:00:00Z.
• Предметы: article
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Abstract Mycophenolic acid (MPA) inhibits IMPDH, involved in the guanosine nucleotides synthesis, and prevents DNA replication in immune cells. The repression of cell and humoral immunity by MPA induces allograft tolerance preventing acute rejection in solid organ transplantation. MPA is an effectiv...