Pharmacogenomics of mycophenolic acid in kidney transplantation: Contribution of immune response-related genes

• Main Authors: Rosario Dominguez Crespo Hirata (Author), Fabiana Dalla Vecchia Genvigir (Author), Thiago Dominguez Crespo Hirata (Author), Alvaro Cerda (Author), Mario Hiroyuki Hirata (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Mycophenolic acid (MPA) inhibits IMPDH, involved in the guanosine nucleotides synthesis, and prevents DNA replication in immune cells. The repression of cell and humoral immunity by MPA induces allograft tolerance preventing acute rejection in solid organ transplantation. MPA is an effectiv...