Long-Lasting Anti-emetic Effect of T-2328, a Novel NK1 Antagonist

• Prif Awduron: Yumi Watanabe (Awdur), Masahito Okamoto (Awdur), Taketoshi Ishii (Awdur), Satomi Takatsuka (Awdur), Hiroyuki Taniguchi (Awdur), Masaaki Nagasaki (Awdur), Akira Saito (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2008-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The effect of T-2328 {2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl] amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride}, a novel tachykinin NK1-receptor antagonist, was examined on cisplatin-induced emesis in ferrets. Cisplatin induced acute emesis in 24 h and de...