Long-Lasting Anti-emetic Effect of T-2328, a Novel NK1 Antagonist

• Main Authors: Yumi Watanabe (Author), Masahito Okamoto (Author), Taketoshi Ishii (Author), Satomi Takatsuka (Author), Hiroyuki Taniguchi (Author), Masaaki Nagasaki (Author), Akira Saito (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effect of T-2328 {2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl] amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride}, a novel tachykinin NK1-receptor antagonist, was examined on cisplatin-induced emesis in ferrets. Cisplatin induced acute emesis in 24 h and de...