Investigations of the novel checkpoint kinase 1 inhibitor SRA737 in non-small cell lung cancer and colorectal cancer cells of differing tumour protein 53 gene status

• Main Authors: Ali JN Duabil (Author), Christian R Cooper (Author), Esraa Aldujaily (Author), Sarah ER Halford (Author), Sandra Hirschberg (Author), Sidath D Katugampola (Author), George DD Jones (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: In response to DNA damage the serine/threonine-specific protein kinase checkpoint kinase 1 (CHK1) is activated allowing cells to enter S phase (S) and G2 phase (G2) cell-cycle arrest. CHK1 inhibitors are expected to prevent cells from entering such arrest, thereby enhancing DNA damage-induced c...