Ocular mucoadhesive and biodegradable spanlastics loaded cationic spongy insert for enhancing and sustaining the anti-inflammatory effect of prednisolone Na phosphate; Preparation, I-optimal optimization, and In-vivo evaluation

• Main Authors: Mayada Said (Author), Khaled M. Ali (Author), Munerah M. Alfadhel (Author), Obaid Afzal (Author), Basmah Nasser Aldosari (Author), Maha Alsunbul (Author), Rawan Bafail (Author), Randa Mohammed Zaki (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to formulate and statistically optimize spanlastics loaded spongy insert (SPLs-SI) of prednisolone Na phosphate (PRED) to enhance and sustain its anti-inflammatory effect in a controlled manner. An I-optimal optimization was employed using Design-Expert® software. The formulation va...