Erythropoietin Attenuates Postoperative Cognitive Dysfunction by Shifting Macrophage Activation toward the M2 Phenotype

• Main Authors: Jae Hoon Lee (Author), Eun Hee Kam (Author), So Yeon Kim (Author), So Yeong Cheon (Author), Eun Jung Kim (Author), Seungsoo Chung (Author), Ji-Hyun Jeong (Author), Bon-Nyeo Koo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Postoperative cognitive dysfunction (POCD) may be driven by transference of the innate immune response to the brain after aseptic surgical damage. Macrophages are key mediators of innate immunity that can display a pro-inflammatory M1 phenotype or an anti-inflammatory M2 phenotype. Erythropoietin (E...