Upregulation of Store Operated Ca2+ Channel Orai1, Stimulation of Ca2+ Entry and Triggering of Cell Membrane Scrambling in Platelets by Mineralocorticoid DOCA

• Main Authors: Guoxing Liu (Author), Guilai Liu (Author), Kousi Alzoubi (Author), Anja T. Umbach (Author), Lisann Pelzl (Author), Oliver Borst (Author), Meinrad Gawaz (Author), Florian Lang (Author)
• Format: Book
• Published: Karger Publishers, 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Mineralocorticoid excess leads to vascular injury, which is partially due to hypertension but in addition involves increased concentration of cytosolic Ca2+ concentration in platelets, key players in the pathophysiology of occlusive vascular disease. Mineralocorticoids are in part e...