A model‐based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno‐oncology

• Main Authors: Javier Sánchez (Author), Christina Claus (Author), Rosmarie Albrecht (Author), Brenda C. Gaillard (Author), Joana Marinho (Author), Christine McIntyre (Author), Tamara Tanos (Author), Axel Boehnke (Author), Lena E. Friberg (Author), Siv Jönsson (Author), Nicolas Frances (Author)
• Format: Book
• Published: Wiley, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract FAP‐4‐1BBL is a bispecific antibody exerting 4‐1BB‐associated T‐cell activation only while simultaneously bound to the fibroblast activation protein (FAP) receptor, expressed on the surface of cancer‐associated fibroblasts. The trimeric complex formed when FAP‐4‐1BBL is simultaneously bound...