Formononetin Attenuates Renal Tubular Injury and Mitochondrial Damage in Diabetic Nephropathy Partly via Regulating Sirt1/PGC-1α Pathway

• Main Authors: Qunwei Huang (Author), Hongbo Chen (Author), Kai Yin (Author), Yilan Shen (Author), Kanghong Lin (Author), Xieyi Guo (Author), Xiang Zhang (Author), Niansong Wang (Author), Wenfeng Xin (Author), Youhua Xu (Author), Dingkun Gui (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial abnormality is one of the main factors of tubular injury in diabetic nephropathy (DN). Formononetin (FMN), a novel isoflavonoid isolated from Astragalus membranaceus, has diverse pharmacological activities. However, the beneficial effects of FMN on renal tubular impairment and mitochon...