The proximal promoter region of <it>mTert </it>is sufficient to regulate telomerase activity in ES cells and transgenic animals

• Main Authors: Pintado Belen (Author), Nieto Marta (Author), Maria Torres Juan (Author), Relaño-Gines Aroa (Author), Villa-Diaz Ana (Author), Ramírez Miguel (Author), Pericuesta Eva (Author), Gutiérrez-Adán Alfonso (Author)
• Format: Book
• Published: BMC, 2006-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The reverse transcriptase of telomerase (Tert) controls telomerase activity maintaining the end of linear chromosomes in eukaryotic cells. Telomerase function is highly active in undifferentiated multipotent stem cells, decreases wit...