Functional characterization of the defective CYP2C9 variant CYP2C9*18

• Main Authors: Jian Liu (Author), Hao Chen (Author), Shuang‐Hu Wang (Author), Quan Zhou (Author), Pei‐Wu Geng (Author), Yun‐Fang Zhou (Author), Hua‐Lan Wu (Author), Hai‐Feng Shi (Author), Fang Wang (Author), Jie‐Fu Yang (Author), Jian‐Ping Cai (Author), Da‐Peng Dai (Author)
• Format: Book
• Published: Wiley, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Cytochrome P450 2C9 (CYP2C9) is one of the most important drugs metabolizing enzymes and accounts for the metabolism of about 13%-17% of clinical drugs. Like other members in CYP2 family, CYP2C9 gene exhibits great genetic polymorphism among different races and individuals. CYP2C9*18 is one...