Cover Image

Functional characterization of the defective CYP2C9 variant CYP2C9*18

Abstract Cytochrome P450 2C9 (CYP2C9) is one of the most important drugs metabolizing enzymes and accounts for the metabolism of about 13%-17% of clinical drugs. Like other members in CYP2 family, CYP2C9 gene exhibits great genetic polymorphism among different races and individuals. CYP2C9*18 is one...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jian Liu (Author), Hao Chen (Author), Shuang‐Hu Wang (Author), Quan Zhou (Author), Pei‐Wu Geng (Author), Yun‐Fang Zhou (Author), Hua‐Lan Wu (Author), Hai‐Feng Shi (Author), Fang Wang (Author), Jie‐Fu Yang (Author), Jian‐Ping Cai (Author), Da‐Peng Dai (Author)
Format:	Book
Published:	Wiley, 2021-02-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Identification and drug metabolic characterization of four new CYP2C9 variants CYP2C9*72-*75 in the Chinese Han population
by: Fang-Ling Zhao, et al.
Published: (2022)

Distribution of polymorphisms in the CYP2C9 gene and CYP2C19/CYP2C9 haplotypes among Venezuelan populations
by: Sara Flores-Gutiérrez, et al.
Published: (2017)

Characterisation of <it>CYP2C8</it>, <it>CYP2C9 </it>and <it>CYP2C19 </it>polymorphisms in a Ghanaian population
by: Dodoo Alexander NO, et al.
Published: (2009)

Function of 38 variants CYP2C9 polymorphism on ketamine metabolism in vitro
by: Xiang Zheng, et al.
Published: (2017)

CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants
by: Lingxin Zhang, et al.
Published: (2020)

Effect of iguratimod on diclofenac metabolism by CYP2C9 in rats and human recombinant CYP2C9 yeast cells
by: Muhammad Usman, et al.

Characterization of a Novel CYP2C9 Mutation (1009C>A) Detected in a Warfarin-Sensitive Patient
by: Shun-Bin Luo, et al.
Published: (2014)

Identification and Enzymatic Activity Evaluation of a Novel CYP2C9 Allelic Variant Discovered in a Patient
by: Xiao-Yang Zhou, et al.
Published: (2021)

Genetic variability of CYP2D6, CYP2B6, CYP2C9 and CYP2C19 genes across the Italian Peninsula
by: Francesco Carano, et al.
Published: (2018)

Pharmacogenetic variants of CYP2C9 and CYP2C19 associated with adverse reactions induced by antiepileptic drugs used in Peru
by: Angel T. Alvarado, et al.
Published: (2023)

Does celecoxib inhibit agomelatine metabolism via CYP2C9 or CYP1A2?
by: Yasar U
Published: (2018)

Associations of CYP2C9 and CYP2C19 Pharmacogenetic Variation with Phenytoin‐Induced Cutaneous Adverse Drug Reactions
by: Alison E. Fohner, et al.
Published: (2020)

The Effect of UGT1A9, CYP2B6 and CYP2C9 Genes Polymorphism on Propofol Pharmacokinetics in Children
by: Pavlovic D, et al.
Published: (2020)

The effect of CYP2C9*2, CYP2C9*3, and VKORC1-1639 G>A polymorphism in patients under warfarin therapy in city of Kermanshah
by: Zohreh Hosseinkhani, et al.
Published: (2018)

Impact of CYP2C9‐Interacting Drugs on Warfarin Pharmacogenomics
by: Saaket Agrawal, et al.
Published: (2020)

CYP2C9 polymorphisms in epilepsy: influence on phenytoin treatment
by: Silvado CE, et al.
Published: (2018)

The prevalence of allelic variants of VKORC1, CYP2C9 and CYP4F2 genes in Zaporizhzhia region population
by: M. Yu. Kolesnik, et al.
Published: (2019)

Role of CYP2C9, CYP2C19 and EPHX Polymorphism in the Pharmacokinetic of Phenytoin: A Study on Uruguayan Caucasian Subjects
by: Natalia Guevara, et al.
Published: (2017)

Evaluation of Drug-Drug Interactions of Rucaparib and CYP1A2, CYP2C9, CYP2C19, CYP3A, and P‐gp Substrates in Patients With an Advanced Solid Tumor
by: Jim J. Xiao, et al.
Published: (2019)

Functional Characterisation of Human CYP2C9 Allelic Variants in COS-7 cells
by: Huihui eDu, et al.
Published: (2016)

Strong and Selective Inhibitory Effects of the Biflavonoid Selamariscina A against CYP2C8 and CYP2C9 Enzyme Activities in Human Liver Microsomes
by: So-Young Park, et al.
Published: (2020)

Alpinetin suppresses CYP3A4, 2C9, and 2E1 activity in vitro
by: Hongming Song, et al.
Published: (2022)

Study of the effect of anxiolytic GML-1 on the activity of cytochrome CYP2C9 and CYP1A2 isoforms
by: O. G. Gribakina, et al.
Published: (2019)

Evaluation of the Influence of <i>CYP2C9* 2, CYP2C9*3</i> Gene Polymorphisms on the Efficacy and Safety of Postoperative Analgesia with Ketoprofen in Patients after Cardiac Surgery
by: T. E. Morozova, et al.
Published: (2021)

Comparison of CYP2C9, CYP2C19, CYP2D6, ABCB1, and SLCO1B1 gene-polymorphism frequency in Russian and Nanai populations
by: Sychev DA, et al.
Published: (2017)

Gephyrin and CYP2C9 Genetic Polymorphisms in Patients with Pharmacoresistant Epilepsy
by: El-Tallawy HN, et al.
Published: (2021)

Frequency distribution of polymorphisms of CYP2C19, CYP2C9, VKORC1 and SLCO1B1 genes in the Yakut population
by: Filipp Filippovich Vasilyev, et al.
Published: (2016)

Polymorphisms of VKORC1 and CYP2C9 are associated with warfarin sensitivity in Chinese population
by: Jia LQ, et al.
Published: (2017)

Characterization of 15 CYP2J2 variants identified in the Chinese Han population on the metabolism of ebastine and terfenadine in vitro
by: Li-Li Zou, et al.
Published: (2023)

CYP2C9 mediates the herb-drug interaction of curcumin with naproxen in rats
by: Yongjun Qiu, et al.
Published: (2023)

The allele frequency of CYP2C9 and VKORC1 in the Southern Khorasan population
by: Fariba Emadian Razavi, et al.
Published: (2017)

Exploring the Effect of Compound Glycyrrhizin and Silybinin on the Metabolism of Pexidartinib in Rats Based on CYP3A4 and CYP2C9
by: Yanding Su, et al.
Published: (2023)

Afro-Latin American Pharmacogenetics of <i>CYP2D6</i>, <i>CYP2C9</i>, and <i>CYP2C19</i> in Dominicans: A Study from the RIBEF-CEIBA Consortium
by: Mariela Guevara, et al.
Published: (2024)

CYP2C9, CYPC19 and CYP2D6 gene profiles and gene susceptibility to drug response and toxicity in Turkish population
by: Merve Arici, et al.
Published: (2017)

CYP2C9 Variations and Their Pharmacogenetic Implications Among Diverse South Asian Populations
by: Nizamuddin S, et al.
Published: (2021)

Pharmacokinetic interaction of drugs, the metabolisable cytochrome P450 isoenzyme CYP2C9
by: O. G. Gribakina, et al.
Published: (2020)

Pogostone inhibits the activity of CYP3A4, 2C9, and 2E1 in vitro
by: Guiying Zhang, et al.
Published: (2021)

Prevalence and Accuracy of Information on CYP2D6, CYP2C19, and CYP2C9 Related Substrate and Inhibitor Co-Prescriptions in the General Population: A Cross‐Sectional Descriptive Study as Part of the PharmLines Initiative
by: Muh. Akbar Bahar, et al.
Published: (2020)

VKORC1, CYP2C9 Polymorphisms and clotting factors associated with warfarin maintenance dose
by: Alisara Sangviroon
Published: (2014)

Physcion inhibition of CYP2C9, 2D6 and 3A4 in human liver microsomes
by: Lu Liu, et al.
Published: (2024)