Simulation of the crosstalk between glucose and acetaminophen metabolism in a liver zonation model

• Main Authors: Kazuhiro Maeda (Author), Shuta Hagimori (Author), Masahiro Sugimoto (Author), Yasuyuki Sakai (Author), Masaki Nishikawa (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The liver metabolizes a variety of substances that sometimes interact and regulate each other. The modeling of a single cell or a single metabolic pathway does not represent the complexity of the organ, including metabolic zonation (heterogeneity of functions) along with liver sinusoids. Here, we in...