Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin and PK/PD Modeling against Escherichia coli in Pigs

• Main Authors: Zhixin Lei (Author), Qianying Liu (Author), Jincheng Xiong (Author), Bing Yang (Author), Shuaike Yang (Author), Qianqian Zhu (Author), Kun Li (Author), Shishuo Zhang (Author), Jiyue Cao (Author), Qigai He (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to evaluate the activity of marbofloxacin and establish the optimal dose regimens for decreasing the development of fluoroquinolone resistance in pigs against Escherichia coli with ex vivo pharmacokinetic/pharmacodynamic (PK/PD) modeling. The recommended dose (2 mg/kg body...