Matrine Reverses the Warburg Effect and Suppresses Colon Cancer Cell Growth via Negatively Regulating HIF-1α

• Main Authors: Xiaoting Hong (Author), Linhai Zhong (Author), Yurou Xie (Author), Kaifeng Zheng (Author), Jinglong Pang (Author), Yesen Li (Author), Yifan Yang (Author), Xiaolin Xu (Author), Panying Mi (Author), Hanwei Cao (Author), Wenqing Zhang (Author), Tianhui Hu (Author), Gang Song (Author), Daxuan Wang (Author), Yan-yan Zhan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Warburg effect is a peculiar feature of cancer's metabolism, which is an attractive therapeutic target that could aim tumor cells while sparing normal tissue. Matrine is an alkaloid extracted from the herb root of a traditional Chinese medicine, Sophora flavescens Ait. Matrine has been repo...