Potential anti-neuroinflammatory NF-кB inhibitors based on 3,4-dihydronaphthalen-1(2H)-one derivatives

• Автори: Yue Sun (Автор), Yan-Qiu Zhou (Автор), Yin-Kai Liu (Автор), Hong-Qin Zhang (Автор), Gui-Ge Hou (Автор), Qing-Guo Meng (Автор), Yun Hou (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Nuclear factor kappa B (NF-кB) inhibition represents a new therapeutic strategy for the treatment of neuroinflammatory diseases. In this study, a series of 3,4-dihydronaphthalen-1(2H)-one (DHN; 6a-n, 7a-c) derivatives were synthesised and characterised by NMR and HRMS. We assessed the toxicity and a...