Targeting PD-1/PD-L1 inhibits rejection in a heterotopic tracheal allograft model of lung transplantation

• Main Authors: Taisuke Kaiho (Author), Hidemi Suzuki (Author), Atsushi Hata (Author), Hiroki Matsumoto (Author), Kazuhisa Tanaka (Author), Yuichi Sakairi (Author), Shinichiro Motohashi (Author), Ichiro Yoshino (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immune checkpoint molecules such as programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) have revolutionized the field of lung cancer treatment. As part of our study, we examined the role of these proteins in acute rejection in a mouse model of heterotopic tracheal transplantation. Recipi...