Annexin A5 Inhibits Endothelial Inflammation Induced by Lipopolysaccharide-Activated Platelets and Microvesicles via Phosphatidylserine Binding

• Main Authors: Brent J. Tschirhart (Author), Xiangru Lu (Author), Janice Gomes (Author), Arundhasa Chandrabalan (Author), Gillian Bell (Author), David A. Hess (Author), Guangxin Xing (Author), Hong Ling (Author), Dylan Burger (Author), Qingping Feng (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sepsis is caused by a dysregulated immune response to infection and is a leading cause of mortality globally. To date, no specific therapeutics are available to treat the underlying septic response. We and others have shown that recombinant human annexin A5 (Anx5) treatment inhibits pro-inflammatory...