Development of a human antibody fragment directed against the alpha folate receptor as a promising molecule for targeted application

• Main Authors: Nattihda Parakasikron (Author), Chatchai Chaotham (Author), Pithi Chanvorachote (Author), Chanida Vinayanuwattikun (Author), Visarut Buranasudja (Author), Pornchanok Taweecheep (Author), Kannika Khantasup (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alpha folate receptor (FRα) is currently under investigation as a target for the treatment of patients with non-small-cell lung cancer (NSCLC), since it is highly expressed in tumor cells but is largely absent in normal tissue. In this study, a novel human variable domain of a heavy-chain (VH) antib...