Translational kinetic‐pharmacodynamics of mRNA‐6231, an investigational mRNA therapeutic encoding mutein interleukin‐2

• Main Authors: Ivana Liric Rajlic (Author), Beatriz Guglieri‐Lopez (Author), Nabeel Rangoonwala (Author), Vijay Ivaturi (Author), Linh Van (Author), Simone Mori (Author), Brian Wipke (Author), Douglas Burdette (Author), Husain Attarwala (Author)
• Format: Book
• Published: Wiley, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Regulatory T cells (Tregs) are essential for maintaining immune homeostasis by serving as negative regulators of adaptive immune system effector cell responses. Reduced production or function of Tregs has been implicated in several human autoimmune diseases. The cytokine interleukin 2 plays...