Design, Rational Repurposing, Synthesis, In Vitro Evaluation, Homology Modeling and In Silico Study of Sulfuretin Analogs as Potential Antileishmanial Hit Compounds

• Main Authors: Ahmed H.E. Hassan (Author), Trong-Nhat Phan (Author), Yeonwoo Choi (Author), Suyeon Moon (Author), Joo Hwan No (Author), Yong Sup Lee (Author)
• Format: Bog
• Udgivet: MDPI AG, 2022-08-01T00:00:00Z.
• Fag: article
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Direct growth inhibition of infectious organisms coupled with immunomodulation to counteract the immunosuppressive environment might be a beneficial therapeutic approach. Herein, a library of sulfuretin analogs were developed with potential capabilities to inhibit production of the immunosuppressive...