Prophylactic Effect of Rebamipide on Aspirin-Induced Gastric Lesions and Disruption of Tight Junctional Protein Zonula Occludens-1 Distribution

• Main Authors: Takahiro Suzuki (Author), Norimasa Yoshida (Author), Nami Nakabe (Author), Yutaka Isozaki (Author), Hirokazu Kajikawa (Author), Tomohisa Takagi (Author), Osamu Handa (Author), Satoshi Kokura (Author), Hiroshi Ichikawa (Author), Yuji Naito (Author), Hirofumi Matsui (Author), Toshikazu Yoshikawa (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aspirin and nonsteroidal anti-inflammatory agents are known to induce gastroduodenal complications such as ulcer, bleeding, and dyspepsia. In this study, we examined the prophylactic effect of rebamipide, an anti-ulcer agent with free-radical scavenging and antiinflammatory effect, on acidified aspi...