Assessment of Target Engagement in a First‐in‐Human Trial with Sinbaglustat, an Iminosugar to Treat Lysosomal Storage Disorders
In this first‐in‐human study, the tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple oral doses of sinbaglustat, a dual inhibitor of glucosylceramide synthase (GCS) and non‐lysosomal glucosyl ceramidase (GBA2), were investigated in healthy subjects. The single‐asce...
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स्वरूप: | पुस्तक |
प्रकाशित: |
Wiley,
2021-03-01T00:00:00Z.
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Connect to this object online.3rd Floor Main Library
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A1234.567 |
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प्रति 1 | उपलब्ध |