Proteomics-Based Retinal Target Engagement Analysis and Retina-Targeted Delivery of 17β-Estradiol by the DHED Prodrug for Ocular Neurotherapy in Males

• Main Authors: Katalin Prokai-Tatrai (Author), Khadiza Zaman (Author), Vien Nguyen (Author), Daniel L. De La Cruz (Author), Laszlo Prokai (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2021-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

We examined the impact of 17β-estradiol (E2) eye drops on the modulation of the proteome profile in the male rat retina. With discovery-driven proteomics, we have identified proteins that were regulated by our treatment. These proteins were assembled to several bioinformatics-based networks implicat...