Effect of ASP8062 on morphine self-administration and morphine-induced respiratory suppression in monkeys

ASP8062 is an orally available GABAB receptor positive allosteric modulator (PAM). This study assessed the potential of ASP8062 for treating opioid use disorder (OUD). Three rhesus monkeys were pretreated with ASP8062 (0.3, 1 or 3 mg/kg) by oral administration 1 h prior to a 2-h morphine self-admini...

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Main Authors: Shinobu Akuzawa (Author), Megumi Irie (Author), Masayuki Kanki (Author), Takafumi Shirakawa (Author), Yuichiro Sato (Author)
Format: Book
Published: Elsevier, 2023-04-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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