Structure-based virtual screening of highly potent inhibitors of the nematode chitinase CeCht1

• Main Authors: Wei Chen (Author), Qi Chen (Author), Ashutosh Kumar (Author), Xi Jiang (Author), Kam Y. J. Zhang (Author), Qing Yang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nematode chitinases play vital roles in various physiological processes, including egg hatching, larva moulting, and reproduction. Small-molecule inhibitors of nematode chitinases have potential applications for controlling nematode pests. On the basis of the crystal structure of CeCht1, a represent...