Human cellular immune response to the saliva of Phlebotomus papatasi is mediated by IL-10-producing CD8+ T cells and Th1-polarized CD4+ lymphocytes.

• Main Authors: Maha Abdeladhim (Author), Mélika Ben Ahmed (Author), Soumaya Marzouki (Author), Nadia Belhadj Hmida (Author), Thouraya Boussoffara (Author), Nabil Belhaj Hamida (Author), Afif Ben Salah (Author), Hechmi Louzir (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The saliva of sand flies strongly enhances the infectivity of Leishmania in mice. Additionally, pre-exposure to saliva can protect mice from disease progression probably through the induction of a cellular immune response.We analysed the cellular immune response against the saliva of Phlebotomus pap...