Prospective population pharmacokinetic study of tacrolimus in adult recipients early after liver transplantation: A comparison of Michaelis-Menten and theory-based pharmacokinetic models

• Main Authors: Xiao-Jun Cai (Author), Rui-Dong Li (Author), Jian-Hua Li (Author), Yi-Feng Tao (Author), Quan-Bao Zhang (Author), Cong-Huan Shen (Author), Xiao-Fei Zhang (Author), Zheng-Xin Wang (Author), Zheng Jiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Objective: Tacrolimus, a calcineurin inhibitor widely used as a potent immunosuppressant to prevent graft rejection, exhibits nonlinear kinetics in patients with kidney transplantation and nephrotic syndrome. However, whether nonlinear drug metabolism occurs in adult patients undergoi...