Bioadhesive polymer/lipid hybrid nanoparticles as oral delivery system of raloxifene with enhancive intestinal retention and bioavailability

• Главные авторы: Xinhui Du (Автор), Na Gao (Автор), Xiaoyong Song (Автор)
• Формат: ‌
• Опубликовано: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Предметы: article
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Raloxifene (RLX) is a second-generation selective estrogen receptor modulator used to treat osteoporosis in postmenopausal women. RLX fails to be developed into injectable dosage forms due to poor solubility. Although oral formulations are clinically available, the lower bioavailability (<2%) emb...