ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosis

• Main Authors: Kai Feng (Author), Teng Ye (Author), Xuetao Xie (Author), Jiashuo Liu (Author), Liangzhi Gong (Author), Zhengsheng Chen (Author), Juntao Zhang (Author), Haiyan Li (Author), Qing Li (Author), Yang Wang (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoarthritis (OA) is a common joint degenerative disease which currently lacks satisfactory disease-modifying treatments. Oxidative stress-mediated senescent chondrocytes accumulation is closely associated with OA progression, which abrogates cartilage metabolism homeostasis by secreting senescenc...