Glutathione-Hemin/Hematin Adduct Formation to Disintegrate Cytotoxic Oxidant Hemin/Hematin in Human K562 Cells and Red Blood Cells' Hemolysates: Impact of Glutathione on the Hemolytic Disorders and Homeostasis

• Main Authors: Sofia K. Georgiou-Siafis (Author), Martina K. Samiotaki (Author), Vassilis J. Demopoulos (Author), George Panayotou (Author), Asterios S. Tsiftsoglou (Author)
• Format: Bog
• Udgivet: MDPI AG, 2022-09-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Hemin, an oxidized form of heme, acts as potent oxidant to regulate glutathione (GSH) content in pro-erythroid K562 nucleated cells, via activation of the KEAP1/NRF2 defensive signaling pathway. Moreover, GSH, as an essential metabolite, is involved in the regulation of cell-redox homeostasis and pr...