Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy

• Main Authors: Kamila Butowska (Author), Xuexiang Han (Author), Ningqiang Gong (Author), Rakan El-Mayta (Author), Rebecca M. Haley (Author), Lulu Xue (Author), Wenqun Zhong (Author), Wei Guo (Author), Karin Wang (Author), Michael J. Mitchell (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Evasion of apoptosis is a hallmark of cancer, attributed in part to overexpression of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2). In a variety of cancer types, including lymphoma, Bcl-2 is overexpressed. Therapeutic targeting of Bcl-2 has demonstrated efficacy in the clinic and is the subj...