Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis.

• Main Authors: Tineke Lauwaet (Author), Yukiko Miyamoto (Author), Sozaburo Ihara (Author), Christine Le (Author), Jarosław Kalisiak (Author), Keith A Korthals (Author), Majid Ghassemian (Author), Diane K Smith (Author), K Barry Sharpless (Author), Valery V Fokin (Author), Lars Eckmann (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Giardiasis and other protozoan infections are major worldwide causes of morbidity and mortality, yet development of new antimicrobial agents with improved efficacy and ability to override increasingly common drug resistance remains a major challenge. Antimicrobial drug development typically proceeds...