Comparison of Direct Oral Anticoagulant Use for the Treatment of Non-Valvular Atrial Fibrillation in Pivotal Clinical Trials vs. the Real-World Setting: A Population-Based Study from Southern Italy

• Main Authors: Ylenia Ingrasciotta (Author), Andrea Fontana (Author), Anna Mancuso (Author), Valentina Ientile (Author), Janet Sultana (Author), Ilaria Uomo (Author), Maurizio Pastorello (Author), Paolo Calabrò (Author), Giuseppe Andò (Author), Gianluca Trifirò (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients enrolled into pivotal randomized controlled trials (RCTs) may differ substantially from those treated in a real-world (RW) setting, which may result in a different benefit-risk profile. The aim of the study was to assess the external validity of pivotal RCT findings concerning direct oral a...