Structure of a Cyclic Peptide as an Inhibitor of <i>Mycobacterium tuberculosis</i> Transcription: NMR and Molecular Dynamics Simulations
Background and Objectives: A novel antitubercular cyclic peptide, Cyclo(1,6)-Ac-CLYHFC-NH<sub>2</sub>, was designed to bind at the rifampicin (RIF) binding site on the RNA polymerase (RNAP) of <i>Mycobacterium tuberculosis</i> (MTB). This peptide inhibits RNA elongation in th...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2024-11-01T00:00:00Z.
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