Biological evaluation of 2,3-dioxoindolin-N-phenylacetamide derivatives as potent CDC25B and PTP1B phosphatase inhibitors

• Main Authors: Qing-Hao Jin (Author), Wen-Bo Chen (Author), Ya-Nan Xia (Author), Bing-Yu Liu (Author), Li-Ping Guan (Author)
• 格式: 图书
• 出版: Universidade de São Paulo, 2020-03-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

A series of 2,3-dioxoindolin-N-phenylacetamide derivatives was evaluated for inhibitory activity against CDC25B and PTP1B enzymes. Most of the derivatives showed inhibitory activity against CDC25B (IC50 = 3.2-23.2 µg/mL) and PTP1B (IC50 = 2.9-21.4 µg/mL). Compound 2h showed the most inhibitory activ...