Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line

• Prif Awduron: Myriam González (Awdur), María Ovejero-Sánchez (Awdur), Alba Vicente-Blázquez (Awdur), Manuel Medarde (Awdur), Rogelio González-Sarmiento (Awdur), Rafael Peláez (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and with different substituents on the sulphonamide nitrogen have been synthesised. 21 showed sub-micromolar cytotoxicity against HeLa and HT-29 human tumour cell lines, and were partic...