Isopanduratin A Inhibits Tumor Necrosis Factor (TNF)-α-Induced Nuclear Factor κB Signaling Pathway by Promoting Extracellular Signal-Regulated Kinase-Dependent Ectodomain Shedding of TNF Receptor 1 in Human Lung Adenocarcinoma A549 Cells

• Main Authors: Chihiro Moriwaki (Author), Riho Tanigaki (Author), Yasunobu Miyake (Author), Nghia Trong Vo (Author), Mai Thanh Thi Nguyen (Author), Nhan Trung Nguyen (Author), Truong Nhat Van Do (Author), Hai Xuan Nguyen (Author), Takao Kataoka (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor necrosis factor α (TNF-α) induces the nuclear factor κB (NF-κB) signaling pathway via TNF receptor 1 (TNF-R1). We recently reported that isopanduratin A inhibited the TNF-α-induced NF-κB signaling pathway in human lung adenocarcinoma A549 cells. In the present study, we found that isopandurati...