Direct Thrombin Inhibitor Dabigatran Compromises Pulmonary Endothelial Integrity in a Murine Model of Breast Cancer Metastasis to the Lungs; the Role of Platelets and Inflammation-Associated Haemostasis

• Main Authors: Marta Smeda (Author), Marta Stojak (Author), Kamil Przyborowski (Author), Magdalena Sternak (Author), Joanna Suraj-Prazmowska (Author), Kamil Kus (Author), Katarzyna Derszniak (Author), Agnieszka Jasztal (Author), Agnieszka Kij (Author), Anna Kurpinska (Author), Anna Kieronska-Rudek (Author), Kamila Wojnar-Lason (Author), Elzbieta Buczek (Author), Tasnim Mohaissen (Author), Stefan Chlopicki (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activation of the coagulation cascade favours metastatic spread, but antithrombotic therapy might also have detrimental effects on cancer progression. In this study, we characterized the effects of dabigatran, a direct reversible thrombin inhibitor, on the pulmonary endothelial barrier and metastati...