Second generation androgen receptor antagonist, TQB3720 abrogates prostate cancer growth via AR/GPX4 axis activated ferroptosis

• Main Authors: Zhongqing Zhang (Author), Tianlei Xie (Author), Shun Zhang (Author), Haoli Yin (Author), Xuyu Zhang (Author), Siyuan Zhang (Author), Wei Chen (Author), Ding Yu (Author), Xuefeng Qiu (Author), Wei Zhao (Author), Hongqian Guo (Author), Junlong Zhuang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Prostate cancer (PCa) poses a great threat to humans. The study aimed to evaluate the potential of TQB3720 in promoting ferroptosis to suppress prostate cancer, providing a theoretical basis for PCa therapy.Methods: PCa cells and nude mice models were divided into TQB3720, enzalutamide (ENZ...