Sodium 4-Carboxymethoxyimino-(4-HPR) a Novel Water-Soluble Derivative of 4-Oxo-4-HPR Endowed with In Vivo Anticancer Activity on Solid Tumors

• Main Authors: Valentina Appierto (Author), Paola Tiberio (Author), Elena Cavadini (Author), Loredana Cleris (Author), Sabrina Dallavalle (Author), Loana Musso (Author), Maria G. Daidone (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

4-oxo-N-(4-hydroxyphenyl)retinamide (4-oxo-4-HPR), an active polar metabolite of the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR), was shown to exert promising antitumor activity through at least two independent mechanisms of action. Specifically, differently from 4-HPR and other retinoi...