Chaihu-shugan-san alleviates depression-like behavior in mice exposed to chronic unpredictable stress by altering the gut microbiota and levels of the bile acids hyocholic acid and 7-ketoDCA

• Main Authors: Chong Ma (Author), Dun Yuan (Author), Stephen James Renaud (Author), Ting Zhou (Author), Fan Yang (Author), Yuligh Liou (Author), Xinjian Qiu (Author), Lu Zhou (Author), Ying Guo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chaihu-Shugan-San (CSS) is a traditional botanical drug formula often prescribed to treat depression in oriental countries, but its pharmacotherapeutic mechanism remains unknown. It was recently reported that CSS alters the composition of intestinal microflora and related metabolites such as bile ac...