Synthesis and biological evaluation of (3/4-(pyrimidin-2-ylamino)benzoyl)-based hydrazine-1-carboxamide/carbothioamide derivatives as novel RXRα antagonists

• Main Authors: Jingbo Qin (Author), Jie Liu (Author), Chunxiao Wu (Author), Jianwen Xu (Author), Bowen Tang (Author), Kaiqiang Guo (Author), Xiaohui Chen (Author), Weihao Liu (Author), Tong Wu (Author), Hu Zhou (Author), Meijuan Fang (Author), Zhen Wu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abnormal alterations in the expression and biological function of retinoid X receptor alpha (RXRα) have a key role in the development of cancer. Potential modulators of RXRα as anticancer agents are explored in growing numbers of studies. A series of (4/3-(pyrimidin-2-ylamino)benzoyl)hydrazine-1-car...