Genome-wide association study of lung function and clinical implication in heavy smokers

• Main Authors: Xingnan Li (Author), Victor E. Ortega (Author), Elizabeth J. Ampleford (Author), R. Graham Barr (Author), Stephanie A. Christenson (Author), Christopher B. Cooper (Author), David Couper (Author), Mark T. Dransfield (Author), Mei Lan K. Han (Author), Nadia N. Hansel (Author), Eric A. Hoffman (Author), Richard E. Kanner (Author), Eric C. Kleerup (Author), Fernando J. Martinez (Author), Robert Paine (Author), Prescott G. Woodruff (Author), Gregory A. Hawkins (Author), Eugene R. Bleecker (Author), Deborah A. Meyers (Author), for the SPIROMICS Research Group (Author)
• Format: Book
• Published: BMC, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The aim of this study is to identify genetic loci associated with post-bronchodilator FEV1/FVC and FEV1, and develop a multi-gene predictive model for lung function in COPD. Methods Genome-wide association study (GWAS) of post-bronchodilator FEV1/FVC and FEV1 was performed in 164...