Nicorandil Elevates Tissue cGMP Levels in a Nitric-Oxide-Independent Manner

• Main Authors: Yukiko Minamiyama (Author), Shigekazu Takemura (Author), Seikan Hai (Author), Shigefumi Suehiro (Author), Shigeru Okada (Author), Yoshihiko Funae (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The K+ channel opener nicorandil is a hybrid compound that contains nitrate in its structure. It has been reported that nicorandil can relax vascular tissue in vitro via a mechanism that involves activation of KATP channels and stimulation of soluble guanylyl cyclase. However, it is not known whethe...