A synonymous mutation in IGF-1 impacts the transcription and translation process of gene expression

• Main Authors: S.Y. Wang (Author), Y.Y. Cheng (Author), S.C. Liu (Author), Y.X. Xu (Author), Y. Gao (Author), C.L. Wang (Author), Z.G. Wang (Author), T.Q. Feng (Author), G.H. Lu (Author), J. Song (Author), P.J. Xia (Author), L.L. Hao (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Insulin-like growth factor 1 (IGF-1) is considered to be a crucial gene in the animal development of bone and body size. In this study, a unique synonymous mutation (c.258 A > G) of the IGF-1 gene was modified with an adenine base editor to observe the growth and developmental situation of mutant...