Uncoupling Protein 2 Increases Susceptibility to Lipopolysaccharide-Induced Acute Lung Injury in Mice

• Main Authors: Qin Wang (Author), Jianchun Wang (Author), Mingdong Hu (Author), Yu Yang (Author), Liang Guo (Author), Jing Xu (Author), Chuanjiang Lei (Author), Yan Jiao (Author), JianCheng Xu (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Uncoupling protein 2 (UCP2) is upregulated in patients with systemic inflammation and infection, but its functional role is unclear. We up- or downregulated UCP2 expression using UCP2 recombinant adenovirus or the UCP2 inhibitor, genipin, in lungs of mice, and investigated the mechanisms of UCP2 in...