The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

• Main Authors: Suryaprakash Raichur (Author), Bodo Brunner (Author), Maximilian Bielohuby (Author), Gitte Hansen (Author), Anja Pfenninger (Author), Bing Wang (Author), Jens C. Bruning (Author), Philip Just Larsen (Author), Norbert Tennagels (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Ectopic fat deposition is associated with increased tissue production of ceramides. Recent genetic mouse studies suggest that specific sphingolipid C16:0 ceramide produced by ceramide synthase 6 (CerS6) plays an important role in the development of insulin resistance. However, the therape...