The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

• 主要な著者: Suryaprakash Raichur (著者), Bodo Brunner (著者), Maximilian Bielohuby (著者), Gitte Hansen (著者), Anja Pfenninger (著者), Bing Wang (著者), Jens C. Bruning (著者), Philip Just Larsen (著者), Norbert Tennagels (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2019-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objective: Ectopic fat deposition is associated with increased tissue production of ceramides. Recent genetic mouse studies suggest that specific sphingolipid C16:0 ceramide produced by ceramide synthase 6 (CerS6) plays an important role in the development of insulin resistance. However, the therape...