Influence of Perinatal Factors on Blood Tryptase and Fecal Calprotectin Levels in Newborns
Background: Blood tryptase and fecal calprotectin levels may serve as biomarkers of necrotizing enterocolitis. However, their interpretation may be hindered by the little-known effects of perinatal factors. The aim of this study was to compare the tryptase and calprotectin levels in newborns accordi...
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MDPI AG,
2023-02-01T00:00:00Z.
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| 001 | doaj_ed939f1faf7c4ece99aa148a4c3db758 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Justine Paysal |e author |
| 700 | 1 | 0 | |a Charlotte Oris |e author |
| 700 | 1 | 0 | |a Ugo Troin |e author |
| 700 | 1 | 0 | |a Pierre-Nicolas Limeri |e author |
| 700 | 1 | 0 | |a Jeanne Allard |e author |
| 700 | 1 | 0 | |a Marie Tadrent |e author |
| 700 | 1 | 0 | |a Bruno Pereira |e author |
| 700 | 1 | 0 | |a Etienne Merlin |e author |
| 700 | 1 | 0 | |a Emmanuelle Rochette |e author |
| 700 | 1 | 0 | |a Bertrand Evrard |e author |
| 700 | 1 | 0 | |a Julie Durif |e author |
| 700 | 1 | 0 | |a Vincent Sapin |e author |
| 700 | 1 | 0 | |a Maguelonne Pons |e author |
| 245 | 0 | 0 | |a Influence of Perinatal Factors on Blood Tryptase and Fecal Calprotectin Levels in Newborns |
| 260 | |b MDPI AG, |c 2023-02-01T00:00:00Z. | ||
| 500 | |a 10.3390/children10020345 | ||
| 500 | |a 2227-9067 | ||
| 520 | |a Background: Blood tryptase and fecal calprotectin levels may serve as biomarkers of necrotizing enterocolitis. However, their interpretation may be hindered by the little-known effects of perinatal factors. The aim of this study was to compare the tryptase and calprotectin levels in newborns according to their term, trophicity, and sex. Method: One hundred and fifty-seven premature newborns and 157 full-term newborns were included. Blood tryptase and fecal calprotectin were assayed. Results: Blood tryptase levels were higher in premature than in full-term newborns (6.4 vs. 5.2 µg/L; <i>p</i> < 0.001). In situations of antenatal use of corticosteroids (<i>p</i> = 0.007) and non-exclusive use of human milk (<i>p</i> = 0.02), these levels were also higher. However, in multiple linear regression analyses, only prematurity significantly influenced tryptase levels. Fecal calprotectin levels were extremely wide-ranging and were much higher in female than in male newborns (300.5 vs. 110.5 µg/g; <i>p</i> < 0.001). Conclusions: The differences in tryptase levels according to term could be linked to early aggression of the still-immature digestive wall in premature newborns, in particular, by enteral feeding started early. The unexpected influence of sex on fecal calprotectin levels remains unexplained. | ||
| 546 | |a EN | ||
| 690 | |a blood tryptase | ||
| 690 | |a fecal calprotectin | ||
| 690 | |a newborns | ||
| 690 | |a perinatal factors | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Children, Vol 10, Iss 2, p 345 (2023) | |
| 787 | 0 | |n https://www.mdpi.com/2227-9067/10/2/345 | |
| 787 | 0 | |n https://doaj.org/toc/2227-9067 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ed939f1faf7c4ece99aa148a4c3db758 |z Connect to this object online. |